The phytochemical screening, mineral composition, vitamin c content and anti-bacterial activity of Celosia argentea commonly known as “sokoyokoto” ethanol and aqueous leaf extracts were investigated. Phytochemical analysis (Qualitative and Quantitative) was carried out on the ethanol and aqueous extracts, while the leaf powder was subjected to mineral analysis. Vitamin C content was determined on both the leaf powder and extracts. The anti-bacterial activity of the leaf extracts was evaluated using Staphylococcus aureus, Bacillus cereus, Enterobacter aerogenes, Escherichia coli, Salmonella typhi and Proteus mirabilis as test organisms. Qualitative analysis revealed the presence of alkaloids, phenols, flavonoids, tannins, saponins, sterols, carbohydrates and glycosides. Phenol was the most abundant in both extracts. Mineral analysis revealed the presence of Ca, Fe, Mg, Zn, Mn, Ni and Cu with relatively high amount of Calcium. Vitamin C content of the leaf powder, aqueous and ethanol extracts was found to be 1.060mg/ml, 0.709mg/ml and 0.620mg/ml respectively. At a concentration of 5mg/ml of both aqueous and ethanol extracts, there was inhibition on the test organisms after 24hours of incubation. The aqueous extract had a higher zone of inhibition (8mg/ml-20mg/ml) than the ethanol extract (6mg/ml-12mg/ml). The results of this research revealed the richness of Celosia argentea leaf in terms of beneficial phytochemicals and nutritional content.