The study on zoonotic diseases of parasitic origin affecting domestic animals in Lokoja metropolis was carried out between December 2018 to May 2019. A total of 150 fecal samples of cows, sheep and goats of different breeds of 50 cows, 50 sheep, 50 goats were examined. These samples were processed and screened by direct smear method for the detection of parasitic ova and cysts. A total of 50 cows were infected with gastrointestinal (GI) parasites, while 31(62.0%) out of 50 cows examined were infected with gastrointestinal parasites. Ova of parasites were identified through their morphological features using the available keys. The prevalence rate for cow was (62.0%), goat was (46.0%) while for sheep was (42.0%). This study revealed Fasciola species as the most common parasites in cows in the study area. The most prevalent species of the parasites in cows in this study were Fasciola hepatica (40.0%), Ascaris lumbricodes (20.0%), Balantidum spp. (10.0%), Theileria spp. (12.0%), Blastocytis spp. (4.0%), Taenia spp. (14.0%). A total of fifty (50) goats were sampled in the area, twenty (20) goats were infected with various species of gastrointestinal parasites while thirty (30) goats were not infected. The study reveals an overall prevalence with Hookworm and Fasciola species having the highest prevalence of 8.0% each, Acanthocephela and Ascaris species had 6.0% each, Dictyocaulus species, Taenia spp. Eimeria spp., Isospora spp. and Gardia lamblia 4.0% Trichostronglus species and an insect had the lowest prevalence of 2.0% each.